The former EastEnders actor will play Iago in the Grassroots Shakespeare London production from April 2-26.
Grassroots will be the only company performing in the West End for William
Shakespeare's 450th birthday on April 26. It will be staged at London's
Leicester Square Theatre.Alexandrou is best known for playing Martin Fowler in EastEnders, and has previously performed alongside Harold Pinter.
Regular Grassroots ensemble members Boris Mitkov (Cassio) and Emily Jane Kerr (Emilia) will also star.
Nari Blair-Mangat will play Othello, while the cast is completed by Annabel Bates as Desdemona, Jim Conway as Brabantio, James Law as the Duke of Venice, John McLear as Lodovico, Christian Bart-Gitten as Herald, Helena Doughty as Bianca and Adam Blampied as Roderigo.
Blair-Mangat was nominated for the Ian Charleson Award for his role in Kenneth Branagh's Macbeth, which transfers to Broadway in June.
James Alexandrou said: "I'm honoured to be playing Iago for Grassroots. To be using their Original Practices approach seems a fitting way to celebrate Shakespeare's birthday."
Grassroots recently completed a sell-out Christmas rep season and a further season at the Old Red Lion Theatre.
Back in 2011, Alexandrou told Digital Spy that he was not interested in a return to EastEnders. His on-screen partner Sonia (Natalie Cassidy) recently came back to Albert Square.
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